- Grant Amount – up to $900,000
- Deadline – December 04, 2025
- CLICK HERE TO APPLY
The RFA supports early-stage development, preclinical testing, and initial clinical evaluation of continuous C-peptide monitoring (CCPM) technologies. It seeks sensor platforms that can detect physiological C-peptide levels with high sensitivity, specificity, stability, and suitability for real-world, longitudinal use. While continuous monitoring is the priority, high-frequency or at-home testing technologies are also eligible if they significantly improve current methods.
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The supported work may lead to improved clinical tools, investigational platforms for therapy development, or companion diagnostics. Relevant research includes creating sensors for biological fluids, validating CCPM systems, feasibility and early clinical studies, evaluating sensor performance in vitro, demonstrating detection under physiological conditions, animal model testing, and integrating biosensors into wearable, user-friendly, or at-home devices.
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Applications may request up to $900,000 USD for a period of up to three years, with the exact funding level determined by the scope and overall objectives of the proposal. Breakthrough T1D may consider projects requiring additional time or budget when strongly justified, while also welcoming proposals with significantly smaller budgets.
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All requested funding must align with the proposed studies and take into account available non-Breakthrough T1D resources such as funds, personnel, and other support, as the appropriateness of the budget relative to the project scope forms part of the review criteria. Letters of Intent may be submitted under the designated funding mechanisms.
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This opportunity invites letters of intent from academic and industry researchers proposing innovative approaches to develop technologies that can capture C-peptide signals with the sensitivity required for individuals with Type 1 diabetes, whose physiological concentrations may fall into the picomolar range.
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Eligibility:
- Applications may be submitted by domestic and foreign non-profit organizations, public and
private, such as universities, colleges, hospitals, laboratories, units of state and local
governments, and eligible agencies of the federal government. Applicants must hold an M.D.,D.O., D.M.D., D.V.M., Ph.D., or equivalent and have a faculty position or equivalent at a
college, university, medical school, or other research facility. - To assure continued excellence and diversity among applicants and awardees, Breakthrough T1D welcomes proposals from all qualified individuals and encourages proposals from a broad cross section of researchers and scientists
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